Sugar substitutes, also known as sweeteners, sweeteners, or sugar substitutes, generally refer to food additives that give food a sweet taste. Looking back at the development history of the sugar substitute industry: the application side has gradually evolved from artificially synthesized sweeteners to natural sweeteners, and the overseas market continues to lead the trend of sweetener application. From the emergence of the first generation sweeteners in 1879 to the emergence of the sixth generation sweeteners in 1993, synthetic sweeteners have undergone six updates and iterations; Subsequently, natural sweeteners such as momordica grosvenorii glycoside and steviol glycoside have been approved and applied in the field of food and beverage by all countries in the world. In recent years, with the implementation of sugar reduction policies in various countries and the upgrading of people's healthy consumption, natural sweeteners have become a new favorite in the application of sugar substitutes in overseas markets. In particular, Momordica grosvenorii glycosides are welcomed by sugar free lovers because of their flavor close to sucrose and excellent hypoglycemic properties.